Simulating complex intracellular processes using object-oriented computational modelling.
نویسندگان
چکیده
The aim of this paper is to give an overview of computer modelling and simulation in cellular biology, in particular as applied to complex biochemical processes within the cell. This is illustrated by the use of the techniques of object-oriented modelling, where the computer is used to construct abstractions of objects in the domain being modelled, and these objects then interact within the computer to simulate the system and allow emergent properties to be observed. The paper also discusses the role of computer simulation in understanding complexity in biological systems, and the kinds of information which can be obtained about biology via simulation.
منابع مشابه
Qualitative methods in control of industrial production units
The research in this paper deals with the application of qualitative models and statistical methods in quality control of production procedures of various components of industrial press machines. The qualitative simulation of discrete-event machine systems is often based upon the use of qualitative simulation and discrete-event methods techniques too. In order to describe and analyze machine sy...
متن کاملA Framework for Modelling and Simulating Networks of Cells
Several complex biological phenomena are to be modelled in terms of a large and dynamic network of compartments, where the interplay between inter-compartment and intra-compartment events plays an essential role. Key examples are embryogenesis and morphogenesis processes, where autonomous internal dynamics of cells, as well as cell-to-cell interactions through membranes, are responsible for the...
متن کاملAn object-oriented hierarchical patch dynamics paradigm (HPDP) for modeling complex groundwater systems across multiple-scales
In this paper, we present an object-oriented hierarchical patch dynamics paradigm (HPDP) for modeling complex groundwater systems across multiple-scales e one that has the potential to significantly alleviate the infamous ‘‘curse-of-dimensionality’’ and the associated computational bottlenecks. The HPDP takes advantage of hierarchy theory, divides and conquers complexities, and decouples scale-...
متن کاملInvestigating Patterns for the Process-Oriented Modelling and Simulation of Space in Complex Systems
Complex systems modelling and simulation is becoming increasingly important to numerous disciplines. The CoSMoS project aims to produce a unified infrastructure for modelling and simulating all sorts of complex systems, making use of design patterns and the process-oriented programming model. We provide a description of CoSMoS and present a case study into the modelling of space in complex syst...
متن کاملRainfall-runoff modelling using artificial neural networks (ANNs): modelling and understanding
In recent years, artificial neural networks (ANNs) have become one of the most promising tools in order to model complex hydrological processes such as the rainfall-runoff process. In many studies, ANNs have demonstrated superior results compared to alternative methods. ANNs are able to map underlying relationship between input and output data without prior understanding of the process under in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Progress in biophysics and molecular biology
دوره 86 3 شماره
صفحات -
تاریخ انتشار 2004